Contribution of Prolonged Ischemia and Donor Age to Chronic Renal Allograft Dysfunction

Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction.

As a consequence of an advancing discrepancy between supply of suitable grafts and demand from potential recipients, less than optimal organs are increasingly being used. Although clinical studies demonstrate the involvement of various risk factors, including donor age and duration of ischemia on long-term graft outcome, their individual contribution and correlation has not been followed experi...

Chronic renal allograft dysfunction.

The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...

Interaction between donor and recipient age in determining the risk of chronic renal allograft failure.

OBJECTIVES Donor age is a known risk factor for chronic allograft failure (CAF) in renal transplant recipients. We have recently shown that advanced recipient age is also a risk factor for CAF. To investigate the interaction between donor and recipient age, we analyzed 40,289 primary solitary Caucasian adult renal transplants registered at the United States Renal Data System (USRDS) from 1988 t...

Pathogenesis and Preventive Strategies of Chronic Dysfunction of Renal Allograft

Chronic renal allograft dysfunction: risk factors, immunology and prevention.

INTRODUCTION Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Despite great progress in surgical aspects and immunosupression therapy, long-term graft survival has not been consistent. Chronic allograft dysfunction (CAD) remains a major cause of late grafts failure. REVIEW CAD is a generic term of all causes of chronic renal allograft dysfunction as...